Initial Experience of NIR-II Fluorescence Imaging-Guided Surgery in Foot and Ankle Surgery

• DOI: 10.1016/j.eng.2024.04.011
• Publication Date: 2024-04-26T03:15:56Z
• Authors: Xiaoxiao Fan; Jie Yang; Huwei Ni; Qiming Xia; Xiaolong Liu; Tianxiang Wu; Lin Li; Paras N. Prasad; Chao Liu; Hui Lin; Jun Qian
• Keywords: Fluorescence-lifetime imaging microscopy; Foot (prosody)

Optical imaging in the second near-infrared (NIR-II; 900–1880 nm) window is currently a popular research topic field of biomedical imaging. This study aimed to explore application value NIR-II fluorescence foot and ankle surgeries. A lab-established surgical navigation system was developed used navigate surgeries which enabled obtaining more high-spatial-frequency information higher signal-to-background ratio (SBR) images compared NIR-I images; our result demonstrates that could provide higher-contrast larger-depth surgeons. Three types clinical scenarios (diabetic foot, calcaneal fracture, lower extremity trauma) were included this study. Using technique, we observed ischemic region diabetic before morphological alterations, accurately determined boundary incision, fully assessed blood supply condition flap. can help surgeons precisely judge margins, detect lesions early, dynamically trace perfusion process. We believe portable reliable equipment additional functional fluorescent probes play crucial roles precision surgery.