Associations of blood metal exposure with thyroid hormones in Chinese pregnant women: A cross-sectional study

• DOI: 10.1016/j.envint.2018.10.038
• Publication Date: 2018-10-29T10:28:17Z
• Authors: Jing Guo; Na Lv; Jun Tang; Xue Zhang; Lihe Peng; Xiaofu Du; Shuai Li; Qiong Luo; Dan Zhang; Guangdi Chen
• Keywords: Cross-sectional study

Few epidemiological studies have investigated associations of exposure to multiple metals with thyroid hormone homeostasis, especially for the pregnant women. Among all 1644 participants enrolled in Hangzhou Birth Cohort Study (HBCS) at baseline, a total 915 women complete data interest were analyzed. Eleven measured blood samples collected around 25 weeks gestation. Serum levels hormones including free triiodothyronine (FT3), (TT3), thyroxine (FT4), (TT4) and thyroid-stimulating (TSH) abstracted from medical records. Relationships between tertiles metal (setting lowest tertile as reference) percent changes estimated by multivariable adjusted linear regression models. Five [arsenic (As), selenium (Se), manganese (Mn), nickel (Ni), antimony (Sb)] significantly linked decreased one or more based on trend tests single-metal Percent [95% confidence intervals (CIs)] third remained significant FT3 As [−3.53% (−5.48%, −1.54%)]; TT3 [−4.19% (−7.00%, −1.31%)]; FT4 Mn [−2.05% (−3.49%, −0.58%)], Sb [−1.99% (−3.44%, −0.52%)] multiple-metal Thyroid concentrations reversely related As, among Chinese Additional prospective are warranted confirm causality. Paper capsule: Exposure was associated