Effect of prenatal exposure to per- and polyfluoroalkyl substances on childhood allergies and common infectious diseases in children up to age 7 years: The Hokkaido study on environment and children's health

• DOI: 10.1016/j.envint.2020.105979
• Publication Date: 2020-07-24T11:42:50Z
• Authors: Yu Ait Bamai; Houman Goudarzi; Atsuko Araki; Emiko Okada; Ikuko Kashino; Chihiro Miyashita; Reiko Kishi
• Keywords: Wheeze

Per- and polyfluoroalkyl substances (PFAS) are widely used bio-accumulative chemicals in many industrial household products. Experimental studies reported that exposure to PFAS results immunotoxicity. We have previously prenatal decreased the risk of allergies, while it increased infectious diseases at ages 2 4 years. However, remains unclear whether adverse effects on allergies continue until a reliable age diagnosing allergies. This study aimed investigating prevalence children up 7, from Hokkaido Study. Among mother-child pairs enrolled followed 7 years, 2689 participants with maternal PFAS, 1st trimester pregnancy 7-year-old questionnaire survey data were included this study. Eleven 3rd-trimester plasma measured using ultra-performance liquid chromatography coupled triple quadrupole tandem mass spectrometry. Wheeze, rhino-conjunctivitis, eczema defined International Study Asthma Allergies Childhood (ISAAC) questionnaire. History childhood diagnosed by doctor was assessed mother-reported child's 7. The relative calculated generalized estimating equation models. odds ratio an episode logistic regression analysis, adjusted for potential confounders. various was: wheeze, 11.9%; 11.3%; eczema, 21.0%; chickenpox, 61.5%; otitis media, 55.7%; pneumonia, 30.6%; respiratory syncytial virus infection, 16.8%. Prenatal perfluorooctanoic acid, perfluorodecanoic acid (PFDA), perfluoroundecanoic (PFUnDA) inversely associated perfluorooctanoate (PFOA), perfluorooctane sulfonate, PFUnDA, perfluorododecanoic (PFDoDA), perfluorotridecanoic eczema. For diseases, PFDA PFDoDA pneumonia PFOA RSV infection among not having any siblings (only-one-child). Our corroborate hypothesis immunosuppressive immunomodulating children. These observed years continued additional assessing inflammatory biomarkers along ISAAC questionnaires, doctor-diagnosed longer follow-ups necessary better assess human immune outcomes.