Residence characteristics and risk of nasopharyngeal carcinoma in southern China: A population-based case-control study

• DOI: 10.1016/j.envint.2021.106455
• Publication Date: 2021-02-27T16:46:58Z
• Authors: Yufeng Chen; Ellen T. Chang; Zhiwei Liu; Qing Liu; Yonglin Cai; Zhe Zhang; Guomin Chen; Qi-Hong Huang; Shang-Hang Xie; Su-Mei Cao; Wei-Hua Jia; Yuming Zheng; Yancheng Li; Longde Lin; Ingemar Ernberg; Hongwei Zhao; Ruimei Feng; Guangwu Huang; Yi Zeng; Yi-Xin Zeng; Hans-Olov Adami; Weimin Ye
• Keywords: China; Nasopharyngeal Carcinoma; Logistic regression; Nasopharyngeal Neoplasms; Relative risks; Environmental exposure; 3. Good health; Environmental sciences; 03 medical and health sciences; 0302 clinical medicine; Risk Factors; Case-Control Studies; 11. Sustainability; Humans; GE1-350; Head and neck cancer; Weighted Cox regression

Given the role of exposures related to residence in development nasopharyngeal carcinoma (NPC) has not been well explored, present study aims investigate magnitude and pattern associations for NPC with lifelong residential exposures. We carried out a multi-center, population-based case-control 2533 incident cases 2597 randomly selected population controls southern China between 2010 2014. performed multivariate logistic regression estimate odds ratios (ORs) 95% confidence intervals (CIs) risk associated Compared those living building over lifetime, was higher individuals cottage (OR: 1.56; CI: 1.34–1.81) or boat (3.87; 2.07–7.21). also increased using wood (1.34; 1.03–1.75), coal (1.70; 1.17–2.47), kerosene (3.58; 1.75–7.36) vs. gas/electricity as cooking fuel; water (1.57; 1.34–1.83), river (1.80; 1.47–2.21), spring/pond/stream (2.03; 1.70–2.41) tap source drinking water; houses smaller-sized larger windows bedroom (3.08; 2.46–3.86), hall (1.89; 1.55–2.31) kitchen (1.67; 1.34–2.08); increasing exposure smoke [(1.53; 1.20–1.94) high exposure)] burned incense [(1.59; 1.31–1.95) daily use)]. Weighted Cox analysis corroborated these results. Poorer conditions household air pollution are an NPC. Large-scale studies other populations longitudinal warranted further corroborate findings.