Long-term exposure to ozone and cardiovascular mortality in a large Chinese cohort

• DOI: 10.1016/j.envint.2022.107280
• Publication Date: 2022-05-17T05:57:41Z
• Authors: Shudan Liu; Yi Zhang; Runmei Ma; Xiaofei Liu; Jingyuan Liang; Hongbo Lin; Peng Shen; Jingyi Zhang; Ping Lu; Xun Tang; Tiantian Li; Pei Gao
• Keywords: Stroke

Evidence for the association between long-term exposure to ozone (O3) and cause-specific cardiovascular disease (CVD) mortality is inconclusive, this has rarely been evaluated at high O3 concentrations. We aim evaluate associations CVD in a Chinese population. From 2009 2018, 744,882 subjects (median follow-up of 7.72 years) were included CHinese Electronic health Records Research Yinzhou (CHERRY) study. The annual average concentrations fine particulate matter (PM2.5), which estimated using grids with resolution up 1 × km, assigned community address each subject. outcomes deaths from CVD, ischemic heart (IHD), myocardial infarction (MI), stroke, hemorrhagic/ischemic stroke. Time-varying Cox model adjusted PM2.5 individual-level covariates was used. mean 68.05 μg/m3. hazard ratio per 10 μg/m3 increase 1.22 (95% confidence interval [CI]: 1.13–1.33) overall mortality, 1.08 (0.91–1.29) IHD, 1.21 (0.90–1.63) MI, 1.28 (1.15–1.43) 1.39 (1.16–1.67) hemorrhagic stroke (1.00–1.49) respectively. study showed that without hypertension had higher risk associated (1.66 vs. 1.15, p = 0.01). observed China, independent other factors. This suggested an urgent need control pollution, especially developing countries.