Intermediate- and long-term associations between air pollution and ambient temperature and glycated hemoglobin levels in women of child bearing age

• DOI: 10.1016/j.envint.2022.107298
• Publication Date: 2022-05-14T01:45:57Z
• Authors: Mike Z. He; Itai Kloog; Allan C. Just; Iván Gutiérrez-Avila; Elena Colicino; Martha M. Téllez-...; María Luisa Pizan...; Marcela Tamayo-Ortiz; Alejandra Cantoral; Diana C. Soria-Co...; Andrea A. Baccarelli; Robert O. Wright; Maayan Yitshak-Sade
• Keywords: Glycated hemoglobin

Air pollution has been linked to obesity while higher ambient temperatures typically reduce metabolic demand in a compensatory manner. Both relationships may impact glucose metabolism, thus we examined the association between intermediate- and long-term exposure fine particulate matter (PM2.5) temperature glycated hemoglobin (HbA1c), longer-term marker of control. We assessed 3-month, 6-month, 12-month average air at 1-km2 spatial resolution via satellite remote sensing models (2013–2019), HbA1c four, six, eight years postpartum women enrolled Programming Research Obesity, Growth, Environment Social Stressors (PROGRESS) cohort based Mexico City. PM2.5 were matched participants' addresses confirmed by GPS tracker. Using linear mixed-effects models, with repeated log-transformed values. All included random intercept for each woman adjusted calendar year, season, individual-level confounders (age, marital status, smoking, alcohol consumption level, education level). analyzed 1,265 measurements 484 women. Per 1 µg/m3 increase 3-month 6-month PM2.5, levels increased 0.28% (95% confidence interval (95 %CI): 0.14, 0.42%) %CI: 0.04, 0.52%) respectively. No was seen PM2.5. °C temperature, decreased 0.63% −1.06, −0.21%) 0.61% −1.08, −0.13%), again is not associated HbA1c. Intermediate-term are opposing changes levels, this region high moderate fluctuation. These effects, measurable mid-adult life, portend future risk type 2 diabetes possible heart disease.