Associations between airborne crude oil chemicals and symptom-based asthma

• DOI: 10.1016/j.envint.2022.107433
• Publication Date: 2022-07-27T15:09:59Z
• Authors: Kaitlyn G. Lawrence; Nicole M. Niehoff; Alexander P. Keil; W. Braxton Jackson; Kate Christenbury; Patricia A. Stewart; Mark R. Stenzel; Tran B. Huynh; Caroline P. Groth; Gurumurthy Ramach...; Sudipto Banerjee; Gregory C. Pratt; Matthew D. Curry; Lawrence S. Engel; Dale P. Sandler
• Keywords: BTEX; Wheeze

The 2010 Deepwater Horizon (DWH) oil spill response and cleanup (OSRC) workers were exposed to airborne total hydrocarbons (THC), benzene, toluene, ethylbenzene, o-, m-, p-xylenes n-hexane (BTEX-H) from crude PM2.5 burning/flaring natural gas. Little is known about asthma risk among workers.We assessed the relationship between several spill-related exposures including job classes, THC, individual BTEX-H chemicals, mixture, using data Gulf Long-Term Follow-up (GuLF) Study, a prospective cohort of 24,937 7,671 nonworkers following DWH disaster.Our analysis largely focused on 19,018 without before who had complete exposure, outcome, covariate information. We defined incident 1-3 years exposure both self-reported wheeze physician diagnosis asthma. THC assigned participants based measurement work histories, while used modeled estimates. modified Poisson regression estimate ratios (RR) 95% confidence intervals (CIs) for associations quantile-based g-computation approach explore joint effect mixture risk.OSRC greater than (RR: 1.60, CI: 1.38, 1.85). Higher estimated levels associated with increased in an exposure-dependent manner (linear trend test p < 0.0001). Asthma also increasing chemicals chemical mixture: A simultaneous quartile increase was 1.45 (95% 1.35,1.55). With fewer cases, less apparent physician-diagnosed alone.THC symptoms as well diagnosis.