Human serum lipidomics analysis revealed glyphosate may lead to lipid metabolism disorders and health risks

• DOI: 10.1016/j.envint.2022.107682
• Publication Date: 2022-12-06T17:41:23Z
• Authors: Feng Zhang; Qiulan Zhang; Xin Liu; Mengting Gao; Xin Li; Yifei Wang; Yueyue Chang; Xuemeng Zhang; Zongli Huo; Li Zhang; Jinjun Shan; Baoli Zhu; Weifeng Yao
• Keywords: Mammals; 0301 basic medicine; Glyphosate; 0303 health sciences; Herbicides; Fatty Acids; Lipid Metabolism Disorders; Lipid Metabolism; 3. Good health; Health risks; Environmental sciences; 03 medical and health sciences; Lipidomics; Animals; Humans; GE1-350; Workers; Biomarkers; Glyphosate-exposure

Glyphosate-based herbicides (GBH) are one of the most widely used pesticides worldwide. Industrial workers in glyphosate-based manufacture populations who experience long-term exposure to high glyphosate levels. The impacts on human health important public problem great concern. Up date, potential adverse effects humans or other mammals have been reported multiple studies. However, limited research is available lipid alternations related glyphosate. In fact, perturbations some metabolisms found industrial previous work. This study aims explore serum lipidomic characterization and understand underlying mechanisms risks associated with exposure. A nontargeted lipidomics was conducted investigate 391 samples from general population chemical factory workers. It demonstrated that caused significant 115 differentially expressed lipids. main manifestations were elevation circulating diacylglycerols (DG), cholesteryl esters (CE), ceramides (Cer), sphingomyelins (SM), lysophosphatidylethanolamines (LPE) phosphatidylcholines (PC), decrease ysophosphatidylcholines (LPC), triacylglycerols (TG), fatty acids (FA) phosphatidylethanolamines (PE). total 88 lipids further screened as biomarkers closely using partial correlation analysis, five which (including PC 16:0/18:2; O, 18:0/18:2; 18:0/20:4; O-40:9 CE 18:3) showed excellent superior performance (AUC = 1) evaluate monitor due present work discovered glyphosate-induced risks, including chronic hepatic renal dysfunction, atherosclerosis, cardiovascular disease neurodegenerative diseases a perspective, could inform identification early indicators interpretation biological detect glyphosate-exposed possible.