Exposure to drinking water trihalomethanes and nitrate and the risk of brain tumours in young people

• DOI: 10.1016/j.envres.2021.111392
• Publication Date: 2021-06-01T15:27:42Z
• Authors: Angela Zumel-Marne; Gemma Castaño-Vin...; Juan Alguacil; Cristina M. Villa...; Milena Maule; Esther Gracia-Lav...; Franco Momoli; Daniel Krewski; Charmaine Mohipp; Eleni Petridou; Evdoxia Bouka; Franco Merletti; Enrica Migliore; Sara Piro; Mina Ha; Andrea ’t Mannetje; Amanda Eng; Nuria Aragones; Elisabeth Cardis
• Keywords: Tap water; Bathing

Brain tumours (BTs) are one of the most frequent tumour types in young people. We explored association between tap water, exposure to trihalomethanes (THM) and nitrate neuroepithelial BT risk Analysis water consumption were based on 321 cases 919 appendicitis controls (10-24 years old) from 6 14 participating countries international MOBI-Kids case-control study (2010-2016). Available historical residential concentrations THMs nitrate, available 3 for 86 352 85 343 respectively, modelled combined with subjects' personal patterns estimate ingestion levels population (both pre- postnatal). The mean age participants was 16.6 old 56% male. highest widest ranges found Spain (residential ingested) Italy Korea nitrate. There no amount consumed showering/bathing frequency. Odds Ratios (ORs) relation both postnatal systematically below 1 (OR = 0.37 (0.08-1.73)) average higher than 66 μg/L. For all ORs above 1.80 (0.91-3.55)) 8.5 mg/L, a suggestion trend increased BTs increasing which appeared stronger early life. This, our knowledge, is first this topic Further research required clarify observed associations.