Association of exposure to perfluoroalkyl substances (PFAS) and phthalates with thyroid hormones in adolescents from HBM4EU aligned studies

• DOI: 10.1016/j.envres.2023.116897
• Publication Date: 2023-08-19T07:02:49Z
• Authors: Andrea Rodríguez-...; Elena Salamanca-F...; Elly den Hond; Veerle J. Verheyen; Lucia Fábelová; Lubica Palkovicov...; Susana Pedraza-Díaz; Argelia Castaño; José Vicente Garc...; Sylvie Remy; Eva Govarts; Greet Schoeters; Nicolás Olea; Carmen Freire; Mariana F. Fernández
• Keywords: Chemistry; Perfluoroalkyl substances; Human medicine; Biology; 3. Good health

Perfluoroalkyl substances (PFAS) and phthalates are synthetic chemicals widely used in various types of consumer products. There is epidemiological experimental evidence that PFAS may alter thyroid hormone levels; however, studies children adolescents limited.To investigate the association exposure to phthalate with serum levels hormones European adolescents.A cross-sectional study was conducted 406 female 327 male (14-17 years) from Belgium, Slovakia, Spain participating Aligned Studies HBM4EU Project (FLEHS IV, PCB cohort, BEA, respectively). Concentrations perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic (PFNA), free thyroxine (FT4), triiodothyronine (FT3), thyroid-stimulating (TSH) were measured sera participants, urinary metabolites six (DEP, DiBP, DnBP, BBzP, DEHP, DiNP) non-phthalate plasticizer DINCH® quantified spot urine samples. Associations assessed linear regression g-computational models for mixtures. Effect modification by sex examined.In females, PFOA mixture concentrations associated lower FT4 higher FT3 MEP sums DiNP, (∑DEHP, ∑DiNP, ∑DINCH) FT4; ∑DEHP FT3; phthalate/DINCH® metabolite FT3. In males, TSH FT4/TSH ratio; ∑DiNP MBzP, ∑DEHP, FT4/TSH. PFOA, mono-(2-ethyl-5-hydroxyhexyl) (OH-MEHP), mono-(2-ethyl-5-oxohexyl) (oxo-MEHP), monocarboxyoctyl (MCOP) made greatest contribution effect.Results suggest sex-specific differences adolescents.