Apolipoprotein Profile in Early Pregnancy and the Link to Gestational Diabetes Mellitus: Insights From Odense Child Cohort

• DOI: 10.1016/j.eprac.2025.02.009
• Publication Date: 2025-02-17T17:05:02Z
• Authors: Kaja K. Faurø; Lasse M. Obel; Henrik T. Christesen; Dorte M. Jensen; Tina K. Jensen; Dorte Glintborg; Marianne S. Andersen; Martin Overgaard

We aimed to investigate potential associations between serum apolipoprotein levels in early pregnancy and the risk of gestational diabetes mellitus (GDM) adverse outcomes. This was an observational study population-based Odense Child Cohort. Pregnant women were followed from inclusion until childbirth. Apolipoprotein levels, including 12 apolipoproteins (ApoA-I, ApoA-II, ApoA-IV, ApoB, ApoC-I, ApoC-II, ApoC-III, ApoD, ApoE, ApoH, ApoJ, ApoM) measured by targeted proteomics using liquid chromatography mass spectrometry on late first trimester samples stored a biobank. GDM defined WHO 2013 diagnostic criteria. A total 991 pregnant included, which 415 (41.9%) diagnosed with GDM. associated increasing ApoB (adjusted OR: 1.26, P = 0.002) ApoD 0.84, 0.021). correlated significantly positively insulin resistance (r 0.22, < 0.001) beta-cell function 3rd 0.20, 0.001), whereas inversely -0.14, -0.12, 0.001). Finally, high lower large-for-gestational-age (LGA) infants 0.78, 0.041). High low independently increased GDM, LGA (low only), suggesting roles for future management