Effect of diclofenac and naproxen and their mixture on spring barley seedlings and Heterocypris incongruens

Chlorophyll 0106 biological sciences Diclofenac Proline Anti-Inflammatory Agents, Non-Steroidal Hordeum Hydrogen Peroxide Carotenoids 01 natural sciences 6. Clean water 3. Good health Naproxen Seedlings Crustacea Malondialdehyde Animals Drug Interactions Oxidoreductases Plant Proteins 0105 earth and related environmental sciences
DOI: 10.1016/j.etap.2021.103746 Publication Date: 2021-09-15T15:51:22Z
ABSTRACT
Nonsteroidal anti-inflammatory drugs (NSAIDs) are a popular group of drugs used worldwide. These drugs are also available over the counter, which implies that their consumption is not strictly regulated. They are released through wastewater and feces and can have adverse effects on the environment. The present study aimed to evaluate the effect of two NSAIDs, diclofenac (DCF) and naproxen (NAP), and their mixture (DCF + NAP) on spring barley seedlings and ostracods Heterocypris incongruens. The tested drugs had a negative impact on bivalve ostracods and the studied plants. DCF was the most toxic toward ostracods, while spring barley seedlings were affected the most by NAP. The application of the tested compounds and their mixture resulted in a decrease in fresh weight yield and the content of photosynthetic pigments. In addition, an increase in H2O2 and proline content and changes in the activity of antioxidant enzymes (POD, APX, CAT, and SOD) were observed.
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