Refractory eosinophilic cystitis controlled with low-dose cyclosporine therapy: A case report

• DOI: 10.1016/j.eucr.2021.101829
• Publication Date: 2021-09-02T06:29:58Z
• Authors: Olufunmilola Adeleye; John S. Trickett; Benjamin L. Wright; Aqsa Khan
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Eosinophilic cystitis; Inflammation and Infection; Cyclosporine; RC870-923; Diseases of the genitourinary system. Urology; 3. Good health

Eosinophilic cystitis (EC) is a rare disease of the bladder with no clear inciting etiology, pathogenesis, or standard treatment. We present the case of a 78-year-old woman with a three-year history of refractory EC with symptoms characterized by urinary frequency, gross hematuria, dysuria, and suprapubic pain. Despite treatment with a silver nitrate instillation, antibiotics, alpha-1 blockers, antihistamines, antimuscarinics, beta-3 agonists, and intravesical steroid injections, her symptoms persisted. She was then trialed on systemic therapies including prednisone, montelukast, and cyclosporine. Upon follow-up after initiation of therapy with low-dose cyclosporine she had an excellent response, both symptomatically and anatomically via cystoscopy.