Scrotal calciphylaxis in a fifty-one-year-old man with end-stage renal disease and prior bacteremia

• DOI: 10.1016/j.eucr.2023.102564
• Publication Date: 2023-09-19T21:28:03Z
• Authors: Piroz Bahar; Jennifer Mancuso; Karthik Ramani; Anastasia Wasylyshyn; George Wasylyshyn; Arvin George
• Keywords: 03 medical and health sciences; 0302 clinical medicine; Inflammation and Infection; RC870-923; Diseases of the genitourinary system. Urology

Isolated, ischemic scrotal lesions are an uncommon manifestation of systemic calciphylaxis. This highly morbid disease seen in patients with end-stage renal disease and other risk factors for small vessel calcification results in tissue necrosis and ulceration. Scrotal calciphylaxis is uncommon and difficult to diagnose in patients with comorbid conditions that cause isolated genital skin lesions, including prior systemic infections. We describe a 51-year-old male with end-stage renal disease on hemodialysis and recent history of bacteremia who developed isolated penile and scrotal ulceration due to calciphylaxis. The patient died two months after presentation despite multidisciplinary care.