Paraneoplastic limbic encephalitis secondary to sertoli cell testicular tumor: A case report

• DOI: 10.1016/j.eucr.2025.102995
• Publication Date: 2025-03-01T07:52:23Z
• Authors: Dar Yoffe; Joseph GR. Paturzo; Alexandra Payne; Erin Hays; Michael Markel; Gaurav Bandi
• Keywords: Limbic Encephalitis

Paraneoplastic Limbic Encephalitis (PLE) is a neurocognitive condition caused by an immune response to neuronal proteins linked malignancy, such as testicular cancer. We report 25-year-old male with cognitive and personality changes. His initial MRI showed vasogenic edema. A subsequent CT scan revealed bilateral hydroceles, follow-up scrotal US uncovered right mass, leading radical orchiectomy that confirmed Sertoli cell tumor. Following immunomodulating therapy, the patient's symptoms near-complete resolution within year. This first documented case of PLE resulting from non-germ