Clinical Trial Protocol for LuTectomy: A Single-arm Study of the Dosimetry, Safety, and Potential Benefit of 177Lu-PSMA-617 Prior to Prostatectomy

• DOI: 10.1016/j.euf.2020.09.021
• Publication Date: 2020-11-07T13:48:20Z
• Authors: Nattakorn Dhiantr...; John Violet; Renu Eapen; Omar Alghazo; Mark Scalzo; Price Jackson; Simon P. Keam; Catherine Mitchell; Paul J. Neeson; Shahneen Sandhu; Scott G. Williams; Daniel Moon; Nathan Lawrentschuk; Arun Azad; Michael S. Hofman; Declan G. Murphy
• Keywords: Male; Prostatectomy; Heterocyclic Compounds, 1-Ring; Prostatic Diseases; 03 medical and health sciences; 0302 clinical medicine; Humans; Dipeptides; Prostate-Specific Antigen; 3. Good health

LuTectomy is an open-label phase 1/2 nonrandomised clinical trial evaluating the dosimetry, efficacy, and toxicity of the lutetium-177-radiolabelled small molecule PSMA-617 in men with high-risk localised/locoregional advanced prostate cancer with high prostate-specific membrane antigen expression who are undergoing radical prostatectomy and pelvic lymph node dissection.