Genomic and Transcriptomic Predictors of Response from Stereotactic Body Radiation Therapy in Patients with Oligoprogressive Renal Cell Carcinoma

• DOI: 10.1016/j.euo.2022.11.006
• Publication Date: 2023-01-05T04:17:09Z
• Authors: Zeynep B. Zengin; Ameish Govindarajan; Nicholas Salgia; Nicolas Sayegh; Nishita Tripathi; Ramya Muddasani; Alex Chehrazi-Raffle; Matthew Feng; Benjamin D. Mercier; Colton Ladbury; Claire Hao; Sabrina Salgia; Neal Chawla; Luis Meza; Jasnoor Malhotra; Nazli Dizman; JoAnn Hsu; Daniela V. Castro; Regina Barragan-C...; Hedyeh Ebrahimi; Errol J. Philip; Mark Chang; Jiaming Zhang; Sara Byron; Yung Lyou; Tanya Dorff; Sumanta K. Pal; Savita Dandapani
• Keywords: 0301 basic medicine; 03 medical and health sciences; Humans; Genomics; Radiosurgery; Transcriptome; Carcinoma, Renal Cell; Kidney Neoplasms; 3. Good health

Stereotactic body radiation therapy (SBRT) has been shown to be safe and effective for delaying systemic treatment change among patients with metastatic renal cell carcinoma (mRCC). In this study, we sought to assess the genomic signatures of patients with mRCC who underwent SBRT for oligoprogression. A total of 30 patients with oligoprogressive disease were identified, the majority of whom had clear cell renal cell carcinoma (83.3%) and were receiving first-line treatment (53.3%). Genomic and transcriptomic sequencing were available in 20 and 16 patients, respectively. Duration of systemic treatment (DOT) was categorized as that prior (DOT[P]) and subsequent (DOT[S]) to radiation treatment. The median DOT(P) and DOT(S) were 15.1 and 18.3 mo, respectively, with a median DOT(S)/DOT(P) ratio of 1.4. Patients who had a DOT(S)/DOT(P) ratio of ≥1 had increased expression in pathways related to cell proliferation and development. In contrast, among patients with a ratio of ≤1, the reactive oxygen species pathway was enriched. This study highlights the potential role of genomics and transcriptomics to refine radiation treatment selection in patients with mRCC. PATIENT SUMMARY: In this study, we looked at mutations and genomic expressions among kidney cancer patients who responded better to stereotactic body radiotherapy. We found that enriched expression of certain pathways might play a role in response to radiotherapy.