Interleukin-6 −174G/C gene polymorphism affects muscle damage response to acute eccentric resistance exercise in elderly obese women

• DOI: 10.1016/j.exger.2013.08.009
• Publication Date: 2013-08-24T20:31:12Z
• Authors: Silvana Schwerz F...; Jonato Prestes; Alessandro de Oli...; Darlan L. Farias; Tatiane G. Teixeira; Denis Cesar Leite...; Vinícius C. Souza; Nuno M.F. Sousa; James W. Navalta; Gislane F. Melo; Margô Gomes de Ol...
• Keywords: 2. Zero hunger; Aging; Interleukin-6; Resistance Training; Middle Aged; Polymorphism, Single Nucleotide; 03 medical and health sciences; 0302 clinical medicine; Humans; Female; Muscle Strength; Obesity; Muscle, Skeletal; Creatine Kinase; Aged

The IL-6 gene polymorphism has been associated with disease prevalence and different physiological responses to exercise. Eccentric resistance exercise (ERE) is considered a nonpharmacological tool to prevent the chronic degenerative profile associated with aging and obesity. Consequently, the aim of the present study was to investigate the influence of IL-6 -174G/C polymorphism on acute interleukin-6 (IL-6) and creatine kinase (CK) temporal response to ERE in elderly obese women. Ninety women completed seven sets of ten repetitions (eccentric only) of an acute ERE session at 110% of the ten repetitions maximum (10RM). IL-6 genotypes displayed no difference at baseline. ERE induced changes in CK concentration over time occurred only in the GG group, F(2.619, 136.173)=5.199, p=0.003, with CK activity increased from 106.8±6.9 U/l pre-intervention to 122.7±11.2 U/l at 24 h and 131.9±14.4 U/l at 48 h post-exercise. IL-6 concentration in the GG group was lower than the CC/CG group only at 0 h post-exercise (3.78±0.58 pg/ml versus 6.51±1.91 pg/ml, p=0.030). Only the GG genotype group had higher CK activity 24-48 h following ERE and greater CK integral values, while IL-6 activity over 48 h was higher in the CC/CG genotype group. In conclusion, IL-6 genotype affects CK and IL-6 in response to ERE. It is of interest that the ERE protocol induced an elevation in CK, indicating possible muscle damage without exacerbating IL-6 and CK for the GG genotype.