Hesperidin inhibits NOX4 mediated oxidative stress and inflammation by upregulating SIRT1 in experimental diabetic neuropathy

• DOI: 10.1016/j.exger.2022.112064
• Publication Date: 2022-12-15T01:08:29Z
• Authors: Anees Ahmed Syed; Mohammad Irshad Reza; Himanshu Yadav; Jiaur R. Gayen
• Keywords: NOX4; Diabetic Neuropathy

Hesperidin possesses myriads of pharmacological benefits, including anti-inflammatory and antioxidant properties. Herein, we speculated that the described benefits hesperidin might be due to its potentiating action on SIRT1; thereby, inhibition NOX4. We developed diabetic neuropathy in Sprague-Dawley rats by feeding them a high-fat diet (HFD) for 12 weeks. checked effect level oxidative stress, inflammatory markers, NOX4, SIRT1 biochemical analysis, histopathology, immunoblotting, immunocytochemistry, real-time qPCR HFD-fed Palmitate encountered rat glial C6 cells. administration improved mechanical, thermal allodynia, glucose homeostasis. There was decrease stress inflammation an enhanced enzymes. Besides, expression NOX4 down-regulated, while upregulated. Interestingly, treatment protected from damage upregulating inhibiting expression.