Resistance training prevents dynamics and mitochondrial respiratory dysfunction in vastus lateralis muscle of ovariectomized rats

• DOI: 10.1016/j.exger.2023.112081
• Publication Date: 2023-01-03T16:30:56Z
• Authors: Cecília Tardivo M...; Anderson Diogo de...; Iara Dinik Santos...; Marina Rodrigues ...; Gabriel Carlos Go...; Diego Felipe Cava...; Fábio Tamanini; André Vessoni Ale...; Anibal Eugênio Ve...; Gilberto Eiji Shi...
• Keywords: FIS1; sed; Endurance Training; MFN1

To investigate whether ovariectomy affects mitochondrial respiratory function, gene expression of the biogenesis markers and dynamics vastus lateralis muscle, female Wistar rats divided into ovariectomized (OVX) intact (INT) groups were kept sedentary (SED) or submitted to resistance training (RT) performed for thirteen weeks on a vertical ladder in which animals climbed with workload apparatus. RT sessions four climbs 65, 85, 95, 100 % rat's previous maximum workload. Mitochondrial Respiratory Function data obtained by High-resolution respirometry. Gene FIS1, MFN1 PGC1-α was evaluated real-time PCR. There decrease oxidative phosphorylation capacity OVX-SED compared other groups. Trained presented increase when For control ratio (RCR), lower values INT-SED trained RCR higher INT-SED. Exercise increased OVX-SED. Our results demonstrated that absence ovarian hormones, there is great electron transfer system capacities animals. able genes related markers, reversing condition determined ovariectomy.