Effect of outer membrane vesicles of Lactobacillus pentosus on Tau phosphorylation and CDK5-Calpain pathway in mice

• DOI: 10.1016/j.exger.2024.112400
• Publication Date: 2024-03-15T06:18:00Z
• Authors: Zhongying Shao; Yanjun Lu; Aihong Xing; Xiying He; Hongyan Xie; Ming Hu
• Keywords: Cognitive Decline

Alzheimer's disease (AD) stands as a neurodegenerative disorder causing cognitive decline, posing significant health concern for the elderly population in China. This study explored effects of outer membrane vesicles (OMVs) from gut microbiota AD patients on learning and memory abilities Tau protein phosphorylation mice. In contrast to OMVs healthy controls PBS treatment group, mice treated with AD-OMVs exhibited notable declines capabilities, evidenced by results Morris water maze, Y-maze, novel object recognition tests. Immunohistochemistry Western blot assessments unveiled elevated levels hyperphosphorylated cortex hippocampus AD-OMVs. However, there were no alterations observed total levels. addition, showed increased neuroinflammation indicated astrocytes microglia. Molecular mechanism studies demonstrated that could activate GSK3β, CDK5-Calpain NF-κB pathways hippocampus. These suggest patient derived can promote host improved neuroinflammation.