Poor sleep quality is associated with probable sarcopenia in community-dwelling older adults: Results from the longevity check-up (lookup) 8+

• DOI: 10.1016/j.exger.2024.112666
• Publication Date: 2024-12-28T00:13:01Z
• Authors: Stefano Cacciatore; Riccardo Calvani; Jasmine Mancini; Francesca Ciciarello; Vincenzo Galluzzo; Matteo Tosato; Emanuele Marzetti; Francesco Landi
• Keywords: Sarcopenia; Aging; Frailty; QH301-705.5; Frailty, Sleep disorders; R; Medicine; Sleep disorders; Sleep quality; Biology (General); Physical performance

Background: Poor sleep quality may contribute to sarcopenia, but evidence remains sparse. This retrospective cross-sectional study investigated the association between subjective sleep quality and probable sarcopenia in a cohort of community-dwelling older adults enrolled in the Longevity Check-Up 8+ study. Methods: Participants were asked about their sleep quality over the past month, with four possible options (“very good”, “quite good”, “quite bad”, very bad”). For the analysis, participants were grouped into good or bad sleep quality categories. Probable sarcopenia was operationalized according to handgrip strength values < 27 kg for men and < 16 kg for women. Logistic regression models were used to explore the relationship between sleep quality and probable sarcopenia. Results: 1971 participants were included in the analysis (mean age 73.4 ± 6.2 years, 50.0 % women). Bad sleep quality was reported by 28.3 % of participants and was more prevalent among women, physically inactive individuals, and those with dyslipidemia. Probable sarcopenia was more prevalent in participants with bad sleep quality (23.8 % vs. 18.7 %, p = 0.012). Logistic regression revealed that bad sleep quality was significantly associated with increased odds of probable sarcopenia in both unadjusted (odds ratio [OR] 1.36, 95 % confidence interval [CI] 1.07–1.72, p = 0.010) and fully adjusted models (OR 1.40, 95 % CI 1.08–1.81, p = 0.011). Conclusions: Poor sleep quality is associated with increased likelihood of probable sarcopenia in older adults. This finding highlights the importance of addressing sleep quality in interventions aimed at preventing sarcopenia and promoting healthy aging.