Trypanosoma cruzi: Effect of the absence of 5-lipoxygenase (5-LO)-derived leukotrienes on levels of cytokines, nitric oxide and iNOS expression in cardiac tissue in the acute phase of infection in mice

• DOI: 10.1016/j.exppara.2010.06.030
• Publication Date: 2010-07-02T08:23:48Z
• Authors: Carolina Panis; Tânia Longo Mazzuco; Cauê Zortéa Ferna...; Vanessa Jacob Vic...; Vera Lúcia Hideko...; Lucy Megumi Yamauchi; Sueli Fumie Yamad...; Rubens Cecchini; Luiz Vicente Rizzo; Phileno Pinge-Filho
• Keywords: Chagas Disease; Mediator

Leukotrienes are important mediators of inflammatory responses. In this study, we investigated the effect absence 5-lipoxygenase (5-LO)-derived leukotrienes on levels cytokines, nitric oxide (NO) and iNOS expression in cardiac tissue mice infected with Trypanosoma cruzi, agent Chagas' disease. NO is a key mediator parasite killing experimentally T. previous studies have suggested that leukotrienes, such as LTB(4), induces synthesis cruzi-infected macrophages plays relevant role NO-dependent manner. We therefore whether would similar vivo controlling burden by regulating activity. made striking observation 5-LO-derived results increased IL-6 production plasma concomitant decrease day 12 after cruzi infection. These findings indicate endogenous regulators activity heart influence without exerting direct action acute phase infection cruzi.