Comparative effectiveness of two lipid emulsions in preventing retinopathy of prematurity in preterm infants requiring parenteral nutrition

• DOI: 10.1016/j.farma.2023.10.005
• Publication Date: 2024-03-30T12:27:21Z
• Authors: Mª José Cabañas Poy; José Bruno Montor...; Félix Castillo Sa...; Nieves Martín-Begué; Susana Clemente B...; Mª Queralt Gorgas...
• Keywords: Male; Parenteral Nutrition; Fat Emulsions, Intravenous; Incidence; Infant, Newborn; Gestational Age; Weight Gain; Soybean Oil; Treatment Outcome; Fish Oils; Humans; Plant Oils; Retinopathy of Prematurity; Female; Olive Oil; Infant, Premature; Phospholipids; Triglycerides; Retrospective Studies

The main aim was to compare the effects of 2 parenteral lipid emulsions on retinopathy prematurity (ROP) incidence, severity, and need for treatment. Secondary effect weight gain in first 6 weeks life. Single-center, observational, retrospective study analyzing preterm infants with a gestational age (GA) < 31 birth 1251 g born between April 2015 December 2018. infants' medical records were reviewed collect clinical data. Parenteral nutrition (PN) details obtained from hospital pharmacy database. In total, 180 patients included: 90 received ClinOleic® SMOFlipid®. No significant differences observed incidence ROP (40% group 41% SMOFlipid® group, p = .88) or requiring treatment (4% 10%, respectively, .152). Weekly similar groups. This showed no difference groups regarding ROP, treatment, weekly el objetivo principal fue comparar los efectos de emulsiones lípidos parenterales sobre la incidencia, gravedad y necesidad tratamiento retinopatía del prematuro (ROP). El secundario efecto aumento peso en las primeras semanas vida. estudio retrospectivo, observacional, unicéntrico, que analizó recién nacidos prematuros con una edad gestacional un al nacer 1.251 g, entre abril diciembre Se revisaron historias clínicas pacientes para recopilar datos clínicos. Los nutrición se obtuvieron base farmacia hospital. total incluyeron pacientes: recibieron observaron diferencias significativas incidencia grupo SMOFlipid®, 0,88) o requería (4 10% respectivamente, 0,152). semanal grupos. este muestra grupos cuanto requiere