On the mechanisms of taurine in alleviating electrocardiographic, hemodynamic, and biochemical parameters following aluminum phosphide cardiotoxicity

• DOI: 10.1016/j.fct.2021.112347
• Publication Date: 2021-06-15T17:12:35Z
• Authors: Mahedeh Samadi; Maryam Baeeri; Hamed Haghi-Aminjan; Mahban Rahimifard; Mahdi Gholami; Shokoufeh Hassani; Mohammadreza Sattari; Yadollah Azarmi; Behnaz Bameri; Maryam Armandeh; Mohammad Reza Hoo...; Mohammad A. Eghbal; Mohammad Abdollahi
• Keywords: Male; Membrane Potential, Mitochondrial; 0301 basic medicine; 0303 health sciences; Cardiotonic Agents; Phosphines; Taurine; Myocardium; Troponin I; Blood Pressure; Heart; Cardiotoxicity; Mitochondria; 3. Good health; Electrocardiography; Oxidative Stress; 03 medical and health sciences; Electron Transport Chain Complex Proteins; Heart Rate; Animals; Rats, Wistar; Aluminum Compounds; Creatine Kinase

Aluminum phosphide (AlP) causes severe cardiotoxicity. Taurine has been chosen for the present study because of its positive known effects on cardiac injuries.To evaluate AlP-induced cardiotoxicity, the animals were divided into seven groups, including the control group, the taurine group (500 mg/kg), AlP with LD50 dose, AlP + taurine 20, 50, 100, and 200 mg/kg group. To assess cardiac hemodynamic parameters, Wistar rats received taurine intraperitoneally 60 min after AlP gavage. Cardiac hemodynamic parameters were evaluated for 180 min. To study biochemical parameters, 24 h after AlP treatment, the animals were sacrificed, and heart tissues were collected.ECG, BP, and HR abnormalities of AlP poisoning were improved by taurine treatment. AlP induced biochemical alterations including complexes I and IV activities, the ADP/ATP ratio, mitochondrial membrane potential, cytochrome C release, and oxidative stress biomarkers ameliorated by taurine. Moreover, taurine improved apoptosis, as well as lessened CK-MB and troponin I levels. Also, there were no significant changes between taurine 500 mg/kg and the control group in tests.The present findings showed that taurine could be a possible candidate for AlP cardiotoxicity treatment via the effect on mitochondrial electron transfer chain and maintaining intracellular ATP balance.