hnRNP‐U enhances the expression of specific genes by stabilizing mRNA

• DOI: 10.1016/j.febslet.2006.11.062
• Publication Date: 2006-12-05T12:11:02Z
• Authors: Masato Yugami; Yasuaki Kabe; Yuki Yamaguchi; Tadashi Wada; Hiroshi Handa
• Keywords: Heterogeneous nuclear ribonucleoprotein; Heterogeneous ribonucleoprotein particle; AU-rich element; Nuclear matrix

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are thought to be involved in pre‐mRNA processing. hnRNP‐U, also termed scaffold attachment factor A (SAF‐A), binds and matrix/scaffold region DNA elements. However, its role the regulation of gene expression is as yet poorly understood. In present study, we show that hnRNP‐U specifically enhances tumor necrosis α mRNA by increasing stability, possibly through binding 3′ untranslated region. We several other genes well, including GADD45A, HEXIM1, HOXA2, IER3, NHLH2, ZFY, stabilizing these mRNAs. These results suggest specific regulating stability.