Angiostatic agents prevent the development of endometriosis-like lesions in the chicken chorioallantoic membrane

• DOI: 10.1016/j.fertnstert.2004.06.080
• Publication Date: 2005-03-05T12:11:39Z
• Authors: Annemiek W. Nap; Gerard A.J. Dunse...; Arjan W. Griffioen; Kevin H. Mayo; Johannes L.H. Evers; Patrick G. Groothuis
• Keywords: Vascular Endothelial Growth Factor A; 0301 basic medicine; O-(Chloroacetylcarbamoyl)fumagillol; Neovascularization, Pathologic; Endometriosis; Angiogenesis Inhibitors; Chick Embryo; Antibodies; Chorioallantoic Membrane; Endostatins; 3. Good health; 03 medical and health sciences; Cyclohexanes; Animals; Female; Chickens; Sesquiterpenes

A prospective study was performed to determine the effects of the angiostatic compounds anti-hVEGF antibody, TNP-470, endostatin, and anginex on the vascularization and on endometriosis-like lesion formation in the chicken chorioallantoic membrane model. Endometriosis-like lesion formation was significantly impaired after treatment with angiostatic agents, which was associated with decreased vessel densities in the surrounding chorioallantoic membrane and more necrosis in the endometriosis-like lesions.