Citrus pectin based complexes for the tetracycline delivery

• DOI: 10.1016/j.fhfh.2022.100100
• Publication Date: 2022-10-22T16:38:23Z
• Authors: Y.V. Chekunkov; S.T. Minzanova; A.V. Khabibullina; D.M. Arkhipova; L.G. Mironova; A.D. Voloshina; A.R. Khamatgalimov; V.A. Milyukov
• Keywords: RC620-627; Nutrition. Foods and food supply; Complexation; TX341-641; Tetracycline; Antimicrobial activity; Nutritional diseases. Deficiency diseases; Pectin; 01 natural sciences; 0104 chemical sciences

This research studied the formation of sodium polygalacturonate complexes with the antimicrobial drug ''Tetracycline''. The formation was confirmed by IR, UV and NMR spectroscopy. It was shown that the complexes were formed by electrostatic attraction and hydrogen bonding. The complexes demonstrated a high degree of drug binding to the polysaccharide matrix with the maximum content of tetracycline (6.68 wt %). The study of the antimicrobial activity of obtained compounds against S. aureus, B. cereus, E. coli showed no decrease in the antimicrobial effect compared to source tetracycline. Thus, the future research towards the new design compounds based on studied complexes could make contribution to a new generation of drugs based on pectin biopolymers.