New triquinane and gymnomitrane sesquiterpenes from fermentation of the basidiomycete Antrodiella albocinnamomea

• DOI: 10.1016/j.fitote.2015.02.005
• Publication Date: 2015-02-20T05:42:58Z
• Authors: Zi-Ming Chen; He-Ping Chen; Fang Wang; Zheng-Hui Li; Tao Feng; Ji-Kai Liu
• Keywords: Molecular Structure; Basidiomycota; Cell Line, Tumor; Fermentation; Humans; Sesquiterpenes; 01 natural sciences; 0104 chemical sciences

Five new triquinane-type sesquiterpenes, antrodins A-E (1-5) and a new gymnomitrane sesquiterpene, antrodin F (6), together with three known compounds 7-9 were isolated from fermentation of Antrodiella albocinnamomea. Their structures were elucidated through extensive spectroscopic methods including 2D NMR and HRMS analyses. The absolute configurations of 1 and 6 were determined using single-crystal X-ray diffraction analyses. The isolated compounds were investigated for their cytotoxicities against five human cancer cell lines.