Controlled assembly of exogenous DNA-based materials in living cells

• DOI: 10.1016/j.fmre.2023.12.009
• Publication Date: 2024-01-16T07:15:43Z
• Authors: Sen Yang; Siqi Li; Chi Yao; Dayong Yang
• Keywords: Rational design

The self-assembly of artificial structures within living cells provides valuable insights into cellular mechanisms and control functions, thereby contributing to advancements in biomedicine synthetic biology. To precisely the intracellular assembly process, exogenous active substances have been introduced, which respond natural environments. Deoxyribonucleic acid (DNA) is a versatile biological macromolecule that has great potential as building block construct biomaterials addition genetic material. Through rational sequence design, DNA molecules can form variety functional structures, enabling precise efficient assembly. These properties greatly enrich forms expand applications molecules. In this review, we summarize controlled DNA-based materials under various stimulating conditions. We highlight three main materials. First, interact with alter environment influence cell behavior fate. Second, assemblies affect subcellular interfere functions. Third, modules enable diagnosis treatment cancers by recognizing for tumor detection, imaging, drug delivery. From effects, review comprehensively summarizes dynamic envisages challenges future research prospects field.