Development of a harmonised method for the profiling of amphetamines

• DOI: 10.1016/j.forsciint.2004.06.020
• Publication Date: 2004-09-08T10:33:15Z
• Authors: Laura Aalberg; Kjell Andersson; Christina Bertler; Hans Borén; Michael D. Cole; Johan Dahlén; Yvonne Finnon; Henk Huizer; Kaisa Jalava; Elisabet Kaa; Eric Lock; Alvaro Lopes; Anneke Poortman-v...; Erkki Sippola
• Keywords: Reductive amination

Reference material was synthesised for 21 substances that are frequently present as synthetic impurities, i.e. by-products, in illicitly produced amphetamine. Each of these substances is a typical by-product for at least one of the three approaches most often used to synthesise amphetamine, namely, the Leuckart, the reductive amination of benzyl methyl ketone, and the nitrostyrene routes. A large body of data on the substances was recorded, including the following: mass spectra, ultraviolet spectra, Fourier transform infrared spectra, infrared spectra in gas phase, and 1H NMR and 13C NMR spectra.