Effect of ultrasonic modification on the protective activity of Flammulina velutipes polysaccharide to prevent ethanol-induced injury on GES-1 cells

• DOI: 10.1016/j.fshw.2023.03.013
• Publication Date: 2023-04-05T23:35:45Z
• Authors: Jinrong Xiao; Xin Chen; Jingsi Zhang; Yifan Wang; Lei Zhong; Qiping Zhan; Qiuhui Hu; Liyan Zhao
• Keywords: Flammulina

Flammulina velutipes (F. velutipes) polysaccharides were modified by ultrasound at the rated power of 150 W and 900 W. The monosaccharide composition, ultraviolet-visible, Fourier transform infrared spectral characteristics F. (FVP) their ultrasonic modification products (U-FVPs) determined. protective effects FVP U-FVPs on human gastric mucosal cells GES-1 confirmed for first time. mole ratios glucose galactose decreased ratio mannose was increased after modification. Compared with original (U-FVP1), (U-FVP2) could better prevent ethanol-induced damage to cells. With increasing intensity, effect FVPs significantly enhanced more effective prevention intracellular reactive oxygen species (ROS) production promotion expression triglyceride factor 2 (TFF2), prostaglandin E2 (PGE2), epidermal growth (EGF), transforming β1 (TGF-β1) mRNA. might be an way develop novel that effectively resist injury caused excessive alcohol consumption.