Gene expression signatures affected by ethanol and/or nicotine in normal human normal oral keratinocytes (NHOKs)

• DOI: 10.1016/j.gdata.2014.06.021
• Publication Date: 2014-06-27T23:00:21Z
• Authors: Jeffrey J. Kim; Omar Khalid; Lewei Duan; Reuben Kim; David Elashoff; Yong Kim
• Keywords: 0301 basic medicine; 570; Nicotine; Oncology and Carcinogenesis; 610; QH426-470; 7. Clean energy; Alcohol Use and Health; Substance Misuse; 03 medical and health sciences; Stem Cell Research - Nonembryonic - Human; Tobacco; Data in Brief; Genetics; 2.1 Biological and endogenous factors; Dental/Oral and Craniofacial Disease; 0303 health sciences; Biomedical and Clinical Sciences; Human Genome; Data management and data science; Gene expression signatures; Pharmacology and Pharmaceutical Sciences; Biological Sciences; Stem Cell Research; 3. Good health; Alcoholism; Good Health and Well Being; 13. Climate action; Biochemistry and Cell Biology; Normal human oral keratinocytes; Alcohol

It has been reported that nicotine/alcohol alter epigenetic control and lead to abrogated DNA methylation histone modifications, which could subsequently perturb transcriptional regulation critically important in cellular transformation. The aim of this study is determine the molecular mechanisms nicotine/alcohol-induced alterations their mechanistic roles human adult stem cells. We hypothesized induces deregulation machinery leads alterations, affect oral epithelial As an initiating step we have profiled transcriptomic induced by combinatory administration EtOH nicotine primary normal keratinocytes. Here provide detailed experimental methods, analysis information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE57634. Our comprehensive map describing changes on