Gene expression signatures affected by ethanol and/or nicotine in normal human normal oral keratinocytes (NHOKs)
0301 basic medicine
570
Nicotine
Oncology and Carcinogenesis
610
QH426-470
7. Clean energy
Alcohol Use and Health
Substance Misuse
03 medical and health sciences
Stem Cell Research - Nonembryonic - Human
Tobacco
Data in Brief
Genetics
2.1 Biological and endogenous factors
Dental/Oral and Craniofacial Disease
0303 health sciences
Biomedical and Clinical Sciences
Human Genome
Data management and data science
Gene expression signatures
Pharmacology and Pharmaceutical Sciences
Biological Sciences
Stem Cell Research
3. Good health
Alcoholism
Good Health and Well Being
13. Climate action
Biochemistry and Cell Biology
Normal human oral keratinocytes
Alcohol
DOI:
10.1016/j.gdata.2014.06.021
Publication Date:
2014-06-27T23:00:21Z
AUTHORS (6)
ABSTRACT
It has been reported that nicotine/alcohol alter epigenetic control and lead to abrogated DNA methylation and histone modifications, which could subsequently perturb transcriptional regulation critically important in cellular transformation. The aim of this study is to determine the molecular mechanisms of nicotine/alcohol-induced epigenetic alterations and their mechanistic roles in transcriptional regulation in human adult stem cells. We hypothesized that nicotine/alcohol induces deregulation of epigenetic machinery and leads to epigenetic alterations, which subsequently affect transcriptional regulation in oral epithelial stem cells. As an initiating step we have profiled transcriptomic alterations induced by combinatory administration of EtOH and nicotine in primary normal human oral keratinocytes. Here we provide detailed experimental methods, analysis and information associated with our data deposited into Gene Expression Omnibus (GEO) under GSE57634. Our data provide comprehensive transcriptomic map describing molecular changes induced by EtOH and nicotine on normal human oral keratinocytes.
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CITATIONS (5)
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