“It was a no-brainer”: A qualitative study of factors driving previvors’ decision-making when considering risk-reducing salpingectomy with delayed oophorectomy

• DOI: 10.1016/j.gore.2022.100948
• Publication Date: 2022-02-26T16:37:33Z
• Authors: Caroline Gellman; Charlotte Ezratty; Julia Schwarz; Valentin Kolev; Stephanie V. Blank
• Keywords: Thematic Analysis; Oophorectomy; Vignette

Previvors are becoming more aware of the option risk-reducing salpingectomy with delayed oophorectomy (RRS-DO) to mitigate their risk ovarian cancer. In this qualitative study, we explored clinical and non-clinical factors that impacted previvors' decision-making pursue RRS-DO as a reduction strategy.Semi-structured telephone interviews were conducted previvors transcribed verbatim. Using ATLAS.ti® software, two primary investigators interpreted data through thematic analysis. After coding four interviews, discussed discrepancies between codes moderator resolved refined code. The applied universal codebook all revised using an iterative approach. Examining within across allowed for major themes patterns emerge.Interviews seventeen (ages 31-46). 6 (25%) had BRCA1 mutation, 7 (41%), BRCA2 3 (13%), Lynch-related 1 (6%), other (MUTYH mutation). At time interview, 12 (71%) planning (6) or undergone RRS-DO, 4 (23%) (1) (3) reducing salpingo-oophorectomy (RRSO), (6%) was undecided. Three emerged: motivating selecting surgical option, barriers complicating decision-making, facilitating decision-making. RRS-DO-focused prioritized avoiding menopause, they also emphasized self-advocacy building rapport providers facilitated decision-making.By understanding priorities experiences, physicians can better partner navigate cancer journey. This will ultimately optimize shared