Metal- and light-free approach to polyheterocycles via a quinone-Cs2CO3 couple promoted regioselective cascade radical cyclization

• DOI: 10.1016/j.gresc.2023.04.001
• Publication Date: 2023-04-03T16:22:55Z
• Authors: Qijing Zhang; Pan Yue; Hao Lei; Cong-Ying Zhou; Chengming Wang
• Keywords: Functional group

A highly efficient, transition-metal- and light-free approach to polyheterocycles via regioselective cascade radical cyclization is developed. The redox-neutral protocol has a broad substrate scope with good functional group tolerance probably undergoes SET process, which initiated by catalytic amounts of quinone in combination 2.0 equiv. Cs2CO3.