Short-term Co-exposure of celery leaf powder exerts detoxifying action against acetaminophen-induced toxicity in fish gills

• DOI: 10.1016/j.hazadv.2022.100148
• Publication Date: 2022-08-17T23:52:45Z
• Authors: Rajasekar Pancham...; Rajarajeshwari Thada; Shivashri Chockal...
• Keywords: Acetaminophen; Fresh water fish

Acetaminophen (APAP) is one of the widely used health care products. After consumption, excess APAP excreted along with its toxic metabolites as human waste into sewage and other aquatic systems. These serve pollutants affect organisms. Plants can remove, reduce transform acetaminophen from contaminated water. Thus, present study aimed at exploring whether + celery leaf powder (CE) exposure would protect fish gills toxicity APAP. The freshwater (Pangasius sutchi) were divided Group 1 control (untreated), 2 treated (500 mg/kg/24 h), 3 CE h) co-exposed 4 control. APAP-exposed fishes displayed elevated levels pollutions markers [aspartate aminotransferase (AST), alanine (ALT), alkaline phosphatase (ALP)], increased oxidative stress markers, altered enzymic non-enzymic antioxidants activities, abnormal histology. Whereas, these changes minimized in APAP+CE exposed fish. findings suggest that antioxidant effect a possible interacting ability phytochemicals could osmoregulatory organs polluted