(23) First Report of the Organ Care System (OCS) Thoracic Organ Perfusion (TOP) Post-Approval Registry

• DOI: 10.1016/j.healun.2023.02.039
• Publication Date: 2023-04-03T09:50:36Z
• Authors: G. Loor; P. Garcha; S. Huddleston; M. Hertz; M. Hartwig; L. Snyder; A. Siddique; H. Strah; J. Kukreja; T. Song; R. Jablonski; M. Smith; R. Walia; A. Arjuna; L. Lozonschi; K. Patel; G. Katlaps; H. Nemeh; E. Suarez; H. Huang; N. Langer; J. Madsen; A. Lee; G. Dhillon; J. MacArthur; S. Keshavamurthy; S. Nandavaram; M. Daneshmand; D. Neujahr; E. Bush; D. Joyce; A. Ardehali; M. Budev; K. McCurry
• Keywords: Solid organ; Organ system

PurposeThe TOP Registry is a multi-center, all-inclusive observational registry that was established to collect perfusion parameters and post-transplant clinical outcomes for lung transplants performed with donor lungs perfused assessed on the OCS Lung system in commercial setting.MethodsRegistry were categorized into three groups according prespecified analysis populations: Standard criteria (SCD), extended (ECD), Other which included retransplants, multi-organ single recipients. All data prospectively collected verified database.ResultsAt time of submission, 318 patients transplanted using system. Complete 262 recipients available analysis. Of these, 70 (26.7%) SCD, 137 (52.3%) ECD, 55 (20.9%) Other. Donor recipient characteristics risk factors similar between groups. Kaplan-Meier survival through 1-year showed 85.7% 82% 80% (p=0.654) Figure 1. Cox regression demonstrated recipients' LAS score at transplantation significant independent predictor mortality (p=0.012) 2.ConclusionThis initial report shows has been used predominantly ECD but also variety other scenarios including multiorgan, transplants. Outcomes all comparable contemporary US determined primarily by recipient's degree illness rather than donor. The setting. database. At 2. This