The beneficial effects of green tea on sleep deprivation-induced cognitive deficits in rats: the involvement of hippocampal antioxidant defense

• DOI: 10.1016/j.heliyon.2021.e08336
• Publication Date: 2021-11-08T16:57:40Z
• Authors: Fatemeh Forouzanfar; Jamileh Gholami; Maryam Foroughnia; Bahareh Payvar; Saeideh Nemati; Mohammad Amin Kho...; Mahsa Saheb; Vahid Hajali
• Keywords: Malondialdehyde; Elevated plus maze

The weight of evidence suggests that sleep is essential for the processes memory consolidation and deprivation (SD) impairs retention long-term in both humans experimental animals, which associated with oxidative stress damage within brain. Green tea polyphenols have revealed carcinogenic, antioxidant, anti-, anti-mutagenic properties. We aimed to investigate possible protective effect green extract (GTE) its main active catechin, epigallocatechin-3-gallate (EGCG), on post-training total (TSD) -induced spatial deficits profile hippocampus rat.Male rats were treated saline, GTE (100 200 mg/kg/day), EGCG (50 mg/kg/day) intraperitoneally 21 days then trained Morris water maze (MWM) a single day protocol. Immediately after end MWM training, animals deprived 6 h by gentle handling method, evaluated memory. Hippocampal levels malondialdehyde, (MDA), thiol was assessed as oxidant antioxidant markers.Spatial impaired TSD group at dose mg/kg/day well 50 could reverse impairment saline-treated levels. Despite unchanged MDA levels, hippocampal significantly decreased increased it basal levels.In conclusion, EGCG, prevent impairments during TSD; probably through normalizing defense system TSD.