Risk of type 2 diabetes mellitus and cardiovascular complications in KCNJ11, HHEX and SLC30A8 genetic polymorphisms carriers: A case-control study

• DOI: 10.1016/j.heliyon.2021.e08376
• Publication Date: 2021-11-17T17:20:36Z
• Authors: Tutun Das Aka; Urmi Saha; Sayara Akter Shati; Md. Abdul Aziz; Mobashera Begum; Md. Saddam Hussain; Md. Shalahuddin M...; Mohammad Sarowar ...; Mohammad Safiqul ...
• Keywords: Heterozygote advantage; genetic model

BackgroundType 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are two deadly diseases caused by the complex interaction of multiple genetic loci, lifestyle environmental factors. Genome-wide association studies described hundreds susceptibility loci for T2DM T2DM-related CVD, but it remains uncertain due to geographic ethnic variations. The objective this study was evaluate associations KCNJ11 rs5219, SLC30A8 rs13266634 HHEX rs1111875 polymorphisms with related CVD.MethodsGenotyping all three performed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method on 250 cases 246 healthy controls. Both descriptive inferential statistical methods were applied MedCalc IBM SPSS software programs analyses.ResultsA significantly increased rs5219 (p<0.05) found in dominant, recessive, heterozygote, homozygote, allele model (aOR = 2.23, 2.03, 1.90, 3.09, 1.80, respectively). For rs13266634, only 3.37, 3.59, 1.79, respectively) showed T2DM. SNP (HHEX) also revealed 2.08, 4.18, 5.93, 2.08-times significant models. Besides, a reduced correlation CVD recessive 0.40 0.65, Again, difference observed between non-CVD patients terms gender distribution, fasting blood glucose (FBG), systolic pressure (SBP), diastolic (DBP), total cholesterol (TC), triglycerides (TG).ConclusionsOur investigation indicates that associated Moreover, is correlated risk CVD.