Alginate/pectin dressing with niosomal mangosteen extract for enhanced wound healing: evaluating skin irritation by structure-activity relationship

• DOI: 10.1016/j.heliyon.2022.e12032
• Publication Date: 2022-12-05T13:22:50Z
• Authors: Philaslak Pooprommin; Chawan Manaspon; Anupma Dwivedi; Anisha Mazumder; Surat Sangkaew; Smith Wanmasae; Jitbanjong Tangpong; Tassanee Ongtanasup; Komgrit Eawsakul
• Keywords: Niosome; Pectin; Dispersity

Most modern wound dressings assist the wound-healing process. In contrast, conventional have limited antibacterial activity and promote sporadic fibroblast growth. Therefore, with prolonged substance release must be improved. This research aimed to develop hydrogel films. These were synthesized from alginate pectin, incorporated mangosteen extract (ME), encapsulated in niosomes (ME-loaded niosomes). Subsequently, we examined vitro physical characteristics of ME-loaded niosomes. included particle pH, size, charge, polydispersity index (PDI), drug loading properties. properties content (DLC), entrapment efficiency (EE), yield (Y). Additionally, swelling ratio biological film. activity, cytotoxicity (L929), cell attachment tested materials, migration, hemocompatibility, vivo irritation. Significant results obtained using a 2:1 niosome preparation containing Span60 cholesterol. Ratio influenced PDI, DLC, EE, Y. The 225.5 ± 5.83 nm, negatively charged, 0.38, 16.2 0.87%, 64.8 3.49%, 87.3 3.09%, respectively. ME was pH sensitive because 85% can released at 5.5 within seven days decrease 70% 7.4. maximum ratios patches 0.5% 1% Ca