High cytotoxicity of a degraded TBBPA, dibromobisphenol A, through apoptotic and necrosis pathways

• DOI: 10.1016/j.heliyon.2023.e13003
• Publication Date: 2023-01-16T17:13:01Z
• Authors: Keitaro Suyama; Hitoshi Kesamaru; Takashi Okubo; Kazumi Kasatani; Keisuke Tomohara; Ayami Matsushima; Takeru Nose
• Keywords: H1-99; 0301 basic medicine; MTT assay; Science (General); Tetrabromobisphenol A; Halogenation; Cytotoxicity; LDH release assay; 3. Good health; Social sciences (General); Q1-390; 03 medical and health sciences; 13. Climate action; HeLa cell; Research Article

Halogenated flame retardants comprising bisphenol A (BPA) derivatives, such as tetrabromobisphenol (TBBPA), have been studied their adverse effects on human health. However, despite the fact that these halogenated BPAs are easily degraded in environment, risks to living organisms due products mostly overlooked. To evaluate potential toxicity of TBBPAs and related compounds, we examined cytotoxicity derivatives possessing one four halogen atoms