Antimicrobial and in silico studies of the triterpenoids of Dichapetalum albidum
H1-99
0303 health sciences
Science (General)
3β-acetoxy-2α,19β-dihydroxy-urs-12-en-28-oic acid
2β, 6β, 21α-trihydroxyfriedelan-3-one
Trypanosoma brucei brucei
3. Good health
Social sciences (General)
Q1-390
03 medical and health sciences
Dichapetalum albidum
Glucose-6-phosphate dehydrogenase
Leishmania donovani
Research Article
DOI:
10.1016/j.heliyon.2023.e18299
Publication Date:
2023-07-14T02:07:24Z
AUTHORS (12)
ABSTRACT
Here we report a new polyhydroxylated triterpene, 2β,6β,21α-trihydroxyfriedelan-3-one (4) isolated from the root and stem bark of Dichapetalum albidum A. Chev (Dichapetalaceae), along with six known triterpenoids (1-3, 5, 6, 8), sitosterol-3β-O-D-glucopyranoside (9), a dipeptide (7), and a tyramine derivative of coumaric acid (10). Friedelan-3-one (2) showed an antimicrobial activity (IC50) of 11.40 μg/mL against Bacillus cereus, while friedelan-3α-ol (1) gave an IC50 of 13.07 μg/mL against Staphylococcus aureus with ampicillin reference standard of 19.52 μg/mL and 0.30 μg/mL respectively. 3β-Acetyl tormentic acid (5) showed an IC50 of 12.50 μg/mL against Trypanosoma brucei brucei and sitosterol-3β-O-d-glucopyranoside (9) showed an IC50 of 5.06 μg/mL against Leishmania donovani with respective reference standards of IC50 5.02 μg/mL for suramin and IC50 0.27 μg/mL for amphotericin B. Molecular docking of the isolated compounds on the enzyme glucose-6-phosphate dehydrogenase (G6PDH) suggested 3β-acetyl tormentic acid (5) and sitosterol-3β-O-D-glucopyranoside (9) as plausible inhibitors of the enzyme in accordance with the experimental biological results observed.
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