The effect of C60 fullerene on the mechanokinetics of muscle gastrocnemius contraction in chronically alcoholized rats

• DOI: 10.1016/j.heliyon.2023.e18745
• Publication Date: 2023-07-27T14:27:03Z
• Authors: Olexandr Motuziuk; Dmytro Nozdrenko; Svitlana Prylutska; Igor Vareniuk; Kateryna Bogutska; Serhii Braniuk; Olexandr Korotkyi; Yuriy Prylutskyy; Uwe Ritter; Jacek Piosik
• Keywords: Gastrocnemius muscle; Muscle tissue; Muscle Fatigue

The C60 fullerene effect (oral administration at a dose of 1 mg kg-1) on the selected biomechanical parameters muscle gastrocnemius contraction, biochemical indicators blood and tissue as well histological changes in rat after chronic alcoholization for 3, 6 9 months was studied detail. Water-soluble fullerenes were shown to reduce pathological processes development apparatus by an average (35-40)%. In particular, they reduced time occurrence fatigue during long-term alcoholic myopathy inhibited oxidative muscle, thereby preventing its degradation. These findings open up possibility using potent antioxidants correction conditions system arising from alcohol intoxication.