Postoperative serum CHI3L1 level is associated with postoperative cognitive dysfunction in elderly patients after hip fracture surgery: A prospective observational study

• DOI: 10.1016/j.heliyon.2023.e18796
• Publication Date: 2023-07-29T06:27:04Z
• Authors: Huiwen Zheng; Qianmin Chen; Jingyue Zhang; Baiqing Ren; Tianya Liu; Chao Liu; Xiaoye Wang; Jingyi Sheng; Zhiping Wang
• Keywords: Postoperative cognitive dysfunction; Univariate analysis

Postoperative cognitive dysfunction (POCD) is a common postoperative complication in older patients. Chitinase-3-like-1 protein (CHI3L1) identified as neuroinflammatory biomarker and impairs function. This study aimed to evaluate the association between serum levels of CHI3L1 POCD explore interleukin-6 (IL-6), IL-1β C-reactive (CRP) elderly after total hip arthroplasty (THA).A 76 patients undergoing THA were enrolled prospective observational study. Serum measured 1 day before surgery other perioperative factors also noted. The correlations mediators inflammation two groups compared via Spearman correlation coefficients. receiver operating characteristic (ROC) curves implemented analyze predictive values inflammatory for POCD. And associated with analyzed by univariate multivariate logistics.POCD was observed 31.6% week surgery. higher than non-POCD [1348.26(778.46-1889.77) VS 2322.86(1686.88-2517.35) ng/ml, P < 0.001]. level positively correlated IL-6 (r = 0.284, 0.013). Compared IL-6, IL-1β, CRP, has highest value area under curve (AUC) 0.779 according ROC curve. By logistic regression analysis, elevated found be an independent risk factor (odds ratio 1.204, 95% confidence interval 1.087-1.332, 0.001).Postoperative significantly incident POCD, THA. may have potential utility further elucidating etiology