Combination therapy of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent leiomyomatosis peritonealis disseminata with endometriosis: A case report

• DOI: 10.1016/j.heliyon.2023.e19794
• Publication Date: 2023-09-02T06:11:22Z
• Authors: Xiaoli Xiao; Cong Wang; Yuyuan Zhang; Fang Li; Huan Zhang; Ruiqing Ma
• Keywords: Hyperthermic Intraperitoneal Chemotherapy; Omentectomy

Leiomyomatosis peritonealis disseminata (LPD) is a non-metastatic, homologous, multicentric benign disorder characterized by small leiomyomas scattered over the peritoneum and omentum. It rare disease with invasive potential. LPD mainly attacks women of childbearing age but has also been reported in post-menopausal women, men, young children. Non-specific clinical imaging findings lead to difficult diagnoses treatment.This study reports case patient recurrent endometriosis after multiple myomectomies hysterectomy, who presented abdominal pain progressive exacerbation. Imaging examinations showed irregular shadows pelvic cavity nodular changes peritoneum, which were considered malignant lesions. A solid mass sized 10 cm × 9 inferior pelvis nodules surface organs detected during surgery. The was treated cytoreductive surgery (CRS), peritonectomy, ovarian ablation, hyperthermic intraperitoneal chemotherapy (HIPEC). challenging, intraoperative bleeding reached 900 ml. However, recovered well achieved tumor-free survival 13 months.It concluded that combination CRS, ovarectomy, HIPEC might be one therapeutic strategies for LPD.