A meta-analysis of the value of serum TSH concentration in the diagnosis of differentiated thyroid cancer in patients with thyroid nodules

• DOI: 10.1016/j.heliyon.2024.e24391
• Publication Date: 2024-01-17T02:02:45Z
• Authors: Xiao-Yu Fan; Wei You; Yao Chen; Chen-Cong Nie; Xue-Lian Wang; Cheng Lei; Juan Song; Huai-Li Luo
• Keywords: Thyroid Nodules

In recent years, most studies believe that high TSH level is positively correlated with the incidence of thyroid cancer, but it still controversial. For this reason, purpose study to analyze correlation between preoperative and malignant nodules using pathological diagnosis as gold standard. To evaluate role serum in predicting malignancy uncertain cytology.As an important member hypothalamus-pituitary-thyroid axis endocrine system, plays a crucial regulating growth, differentiation, function cells (Zhang et al., 2023) [1]. Therefore, has always been considered closely related TC. Currently, have compared levels TC patients individuals benign disease or healthy controls. These findings from various indicated often demonstrate elevated levels, even when their falls within normal range. However, highlight current evidence primarily relies on cross-sectional studies, which mainly describe phenomenon without establishing causal relationships. The involvement early onset late progression remains unknown, interaction other factors how affects not well understood (Gubbi 2020) [2].Symptoms cancer are usually insidious, no obvious clinical symptoms. detection treatment particularly important, improve rate also problem clinicians pay close attention to.