Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches

• DOI: 10.1016/j.heliyon.2024.e25911
• Publication Date: 2024-02-11T22:42:31Z
• Authors: Siwar Ghannay; Budur Saleh Aldha...; Iqrar Ahmad; Abuzar E.A.E. Alb...; Harun Patel; Adel Kadri; Kaiss Aouadi
• Keywords: Acarbose; Isatin; IC50; Docking (animal)

In the development of novel antidiabetic agents, a series isoxazolidine-isatin hybrids were designed, synthesized, and evaluated as dual α-amylase α-glucosidase inhibitors. The precise structures synthesized scaffolds characterized using different spectroscopic techniques elemental analysis. obtained results compared to those reference drug, acarbose (IC