Identification of dual-target isoxazolidine-isatin hybrids with antidiabetic potential: Design, synthesis, in vitro and multiscale molecular modeling approaches

Acarbose Isatin IC50 Docking (animal)
DOI: 10.1016/j.heliyon.2024.e25911 Publication Date: 2024-02-11T22:42:31Z
ABSTRACT
In the development of novel antidiabetic agents, a series isoxazolidine-isatin hybrids were designed, synthesized, and evaluated as dual α-amylase α-glucosidase inhibitors. The precise structures synthesized scaffolds characterized using different spectroscopic techniques elemental analysis. obtained results compared to those reference drug, acarbose (IC
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