Mechanisms with network pharmacology approach of Ginsenosides in Alzheimer's disease

• DOI: 10.1016/j.heliyon.2024.e26642
• Publication Date: 2024-02-19T07:34:25Z
• Authors: Shan He; Junhe Shi; Hua Chai; Lina Ma; Hui Pei; Ping Zhang; Dazhuo Shi; Hao Li
• Keywords: Social sciences (General); H1-99; Q1-390; Science (General); Ginsenosides; Pharmacological mechanisms; Neuroprotective effect; Panax ginseng; Review Article; Alzheimer's disease; Network pharmacology

Alzheimer's disease (AD) is a progressive neurodegenerative characterized by memory loss, cognitive disorder, language dysfunction, and mental disability. The main neuropathological changes in AD mainly include amyloid plaque deposition, neurofibrillary tangles, synapse neuron reduction. However, the current anti-AD drugs do not demonstrate favorable effect altering pathological course of AD. Moreover, long-term use these usually accompanied with various side effects. Ginsenosides are major active constituents ginseng have protective effects on through mechanisms both vivo vitro studies. In this review, we focused discussing therapeutic potential pharmacological activities ginsenosides AD, to provide new insight for further research clinical application future. Recent studies were retrieved from Chinese National Knowledge Infrastructure, Science Technology Library, Wanfang Data, Elsevier, ScienceDirect, PubMed, SpringerLink, Web database up April 2023 using relevant keywords. Network pharmacology bioinformatics analysis used predict against presented wide range biological activities, including alleviating Aβ decreasing tau hyperphosphorylation, regulating cholinergic system, resisting oxidative stress, modulating Ca2+ homeostasis, as well anti-inflammation anti-apoptosis neurons, respectively. For developing applications, network approach was combined summary published