Traditional Chinese medicine treats ulcerative colitis by regulating gut microbiota, signaling pathway and cytokine: Future novel method option for pharmacotherapy

• DOI: 10.1016/j.heliyon.2024.e27530
• Publication Date: 2024-03-06T17:44:47Z
• Authors: Tiancheng Wang; Xinyue Liu; Weijie Zhang; Jing Wang; Tingting Wang; Wei Yue; Lan Ming; Jun Cheng; Juan Sun
• Keywords: Social sciences (General); H1-99; 0301 basic medicine; Q1-390; 03 medical and health sciences; Traditional Chinese medicine; Science (General); Ulcerative colitis; Signaling pathway; Gut microbiota; Review Article; Cytokine

BackgroundUlcerative colitis (UC) is a chronic non-specific inflammatory disease with intestinal tract as the main site. The pathogenic of UC has not yet been clarified, and multiple mechanisms can lead to pathogenesis UC. Traditional Chinese medicine (TCM) offers an opportunity for treatment. TCM become preferred treatment characteristics targets, pathways high safety. This review attempted summarize (compound prescriptions, single herbs, active ingredients) discussed their based on analyzing UC-related gut microbiota, signaling pathway cytokine. In order provide more systematic diverse reference in prevention UC, theoretical clinical UC.Materials methodsThe information was acquired from different databases, including Web Science, PubMed, CNKI, Wanfang, VIP databases. We then focused recent research progress by TCM. Finally, deficiencies future perspectives are proposed.ResultsModern pharmacological studies have shown that compound prescriptions (strengthening spleen, clearing heat removing dampness, toxin), herbs (replenishing Qi, heat, tonifying blood, etc.), ingredients (alkaloids, polysaccharides, flavonoids, polyphenols, terpenes, etc.) efficiency regulating cytokine.ConclusionsTCM achieve its purpose acting ways, deserves further development this field.