Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors

• DOI: 10.1016/j.heliyon.2024.e27531
• Publication Date: 2024-03-06T03:53:44Z
• Authors: Jiangnan Liu; Shuai Yan; Juntong Du; Lizhi Teng; Ru Yang; Peng Xu; Weiyang Tao
• Keywords: Tyrosine kinase inhibitors; Diarrhea; Treatment; Social sciences (General); H1-99; 0301 basic medicine; Q1-390; 03 medical and health sciences; Science (General); Mechanism; Review Article

Tyrosine kinase inhibitors (TKIs) have become first-line drugs for cancer treatment. However, their clinical use is seriously hindered since many patients experience diarrhea after receiving TKIs. The mechanisms of TKI-associated remain unclear. Most existing therapies are symptomatic treatments based on and effects unsatisfactory. Therefore, clarification the underlying critical to develop effective anti-diarrhea drugs. This article summarizes several potential reviews current treatment progress.